منابع مشابه
Mass-spectrometric analysis of glycerophospholipid metabolism
This thesis consists of five parts. In the first part, an automated method for quantitative analysis of phospholipid compositions of cells and tissues by liquid chromatographymass spectrometry was developed. In the second part, this method was applied to investigate brain lipid compositions of patients with progressive epilepsy with mental retardation (EPMR), caused by mutations in the CLN8 gen...
متن کاملDynamics of the Ethanolamine Glycerophospholipid Remodeling Network
Acyl chain remodeling in lipids is a critical biochemical process that plays a central role in disease. However, remodeling remains poorly understood, despite massive increases in lipidomic data. In this work, we determine the dynamic network of ethanolamine glycerophospholipid (PE) remodeling, using data from pulse-chase experiments and a novel bioinformatic network inference approach. The mod...
متن کاملAging-related Changes in Mouse Serum Glycerophospholipid Profiles
OBJECTIVES Metabolic dysfunction is a common hallmark of the aging process and aging-related pathogenesis. Blood metabolites have been used as biomarkers for many diseases, including cancers, complex chronic diseases, and neurodegenerative diseases. METHODS In order to identify aging-related biomarkers from blood metabolites, we investigated the specific metabolite profiles of mouse sera from...
متن کاملAltered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy.
X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal insufficiency. AMN is the most common phenotypic manifestation of adrenoleukodystrophy (X-ALD). In some cases, an inflammatory cerebral demyelination occurs associated to poor prog...
متن کاملSimple assay for glycerophospholipid hydrolase activity of postheparin plasma.
An assay using radioactive substrates is described that permits rapid determinations of glycerophospholipid-hydrolyzing activity in postheparin plasma or its fractions. Optimal conditions are described for hydrolysis of phosphatidylcholine and phosphatidylethanolamine. A minimum of only 2 mul of normal postheparin plasma is used and no extraction of the reaction products is required before thei...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2012
ISSN: 1934-1792
DOI: 10.3180/react_121401.1